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BASIC BIOMEDICAL SCIENCES

Academic year and teacher
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Versione italiana
Academic year
2022/2023
Teacher
STEFANIA HANAU
Credits
7
Didactic period
Primo Semestre

Training objectives

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Modulo: 015421/1 - GENETICA MEDICA
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MEDICAL GENETICS
To provide basic knowledge of formal, human and medical genetics. Use of genetics principles for studying the hereditary diseases.

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Modulo: 52681 - CHIMICA E BIOCHIMICA
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CHEMISTRY AND BIOCHEMISTRY
To give information in basic chemistry, useful in understanding contents of following courses. To give the basis of biochemistry such as energy metabolism and the main classes of macromolecules regulating biochemical processes of living organisms.

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Modulo: 53064 - BIOLOGIA APPLICATA AGLI STUDI BIOMEDICI
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APPLIED BIOLOGY
Know the main functions of the cell and the mechanisms related to the preservation, expression and transmission of genetic information. Know the different biology approaches and techniques applied to diagnostic and scientific laboratories.

Prerequisites

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Modulo: 015421/1 - GENETICA MEDICA (mutua dall'attività formativa GENETICA MEDICA - 015421/1 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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Basic elements of biology, physics and statistics. Basic knowledge of mathematics and general chemistry.

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Modulo: 52681 - CHIMICA E BIOCHIMICA (mutua dall'attività formativa CHIMICA E BIOCHIMICA - 52681 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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Basic elements of biology, physics and statistics. Basic knowledge of mathematics and general chemistry.

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Modulo: 53064 - BIOLOGIA APPLICATA AGLI STUDI BIOMEDICI
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BIOMEDICAL BIOLOGY
Basic elements of biology. Basic knowledge of mathematics and general chemistry.

Course programme

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Modulo: 015421/1 - GENETICA MEDICA (mutua dall'attività formativa GENETICA MEDICA - 015421/1 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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MEDICAL GENETICS
Mendelian genetics: Phenotype, genotype, independence, segregation; Dominance, recessivity, back-cross; Genealogic trees, AD and AR heredity; Probability, Chi-square test, Bayes theorem.
Sex-linked genetics and cytogenetics: Genetic determination of sex; Human normal karyotype; Chromosomal mutations; Lyonization.
Extensions of Mendelian genetics: Multiple alleles, codominance, intermediate dominance, lethal genes; Complementation, gene interaction; Penetrance, variable expressivity, late onset diseases, anticipation; Mitochondrial genetics.
Genetic recombination: Complete and incomplete association; Meiotic crossing-over; Linkage maps.
Genomics: Human genome organization; Eukaryotic gene structure; DNA polymorphisms, gene mutations and mutagenesis.
Elements of quantitative traits and population genetics. Elements of genetics od odontoiatric diseases.

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Modulo: 52681 - CHIMICA E BIOCHIMICA (mutua dall'attività formativa CHIMICA E BIOCHIMICA - 52681 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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CHEMISTRY AND BIOCHEMISTRY
Length and volume measurement units, multiples and submult., mass and weight, density. Physical prop., states of matter, gas and vapor, eq. of state, gas pressure, breathing. Atom, molecules, bonds, periodic t., main elements, ionic compounds, subatomic particles, isotopes. Orbitals and outer electronic configuration. Electronegativity, atomic volume, periodic propert. Metals, ionic, covalent, dative bond, chelant, polar compounds. Electronic delocalization. Magnetism and electrons, radical. Intermolecular forces, water properties. Mole, molecular and formula weights. Naming compounds. Solutions and concentration. Osmolarity, some exerc. Velocity and equilibrium, thermodynamic properties, activation energy, catalyst, law of mass action. pH and buffers. Redox reaction, redox potential concept, galvanic and electrolysis cells. Radioactivity. Organic chemistry in short: structural formula, isomers, asymmetric carbon. Hydrocarbon concept, saturated and unsaturated, aliphatic and aromatic compounds, functional group and radical. Combustion, addition, substitution, polymerization reactions. The different classes of organic compounds. Hemiacetal, acetal, ester, amide. Polyfunctional compounds: hydroxyacids, ketoacids, carbohydrates, aminoacids. Soaps. Nucleophile and electrophile. Basic and acid organic compounds. Radiation chem.
BIOCHEMISTRY
Sugar and fat propert. Amino acid structure and isoelectric point. Protein folding and denaturation. Collagen structure. Iron metabolism and hemoglobin function. Bohr effect. ATP and glycolysis. Krebs cycle. Oxidative phosphorylation.

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Modulo: 53064 - BIOLOGIA APPLICATA AGLI STUDI BIOMEDICI
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BIOMEDICAL BIOLOGY
Biological molecules: carbohydrates, lipids, proteins and nucleic acids
Prokaryotic cells, Eukaryotic cells: organelles. Biological membranes. Cell cycle, mitosis and meiosis. Structure and DNA replication. Genome organization. Transcription and translation
Laboratory techniques of cellular and molecular biology. Transport of membrane. Virus. Cell signaling. Biomaterials. Biology methodologies applied to diagnostic and scientific laboratories.

Didactic methods

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Modulo: 015421/1 - GENETICA MEDICA (mutua dall'attività formativa GENETICA MEDICA - 015421/1 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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Lectures

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Modulo: 52681 - CHIMICA E BIOCHIMICA (mutua dall'attività formativa CHIMICA E BIOCHIMICA - 52681 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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Lectures. FOR CHEMISTRY AND BIOCHEMISTRY
Lectures with slides display, blackboard exercises on solution concentrations and pH arguments with students involvement.

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Modulo: 53064 - BIOLOGIA APPLICATA AGLI STUDI BIOMEDICI
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BIOMEDICAL BIOLOGY
Lectures, including slides that will be made available on the course minisite.

Learning assessment procedures

CHEMISTRY AND BIOCHEMISTRY
Written exam lasting 1 hour and half. Chemistry part: 16 questions with 3 answers for each question, plus 2 more questions with open answer, right question 1 point, wrong or not answered 0 point. Minimal rank to overcome this part is 7, maximal 16 if all is wright. Biochemistry part: 10 multiple choice questions and 5 with open answer. Final mark will be the sum of the chemistry and biochemistry rank. Laude which consists of one more point will be gained if all done is right.
APPLIED BIOLOGY
The oral or written exams will be conducted online or in presence according to the University's indications and guidelines. The test includes a written test consisting of 31 questions, some of which with a closed answer and some open-ended. For each correct answer 1 point. Verification with 31 positive responses on / 31 total, provides a score of 30/30 and laud. The written test lasts 45 minutes. The oral exam will consist of 3 open questions on the topics presented in class.
MEDICAL GENETICS
A partial test of Medical Genetics, including a written test and an oral exam. The written test consists in 11 open-ended questions, covering the main subjects of the module program, and corresponding to medical genetics problems and definitions. The estimated time for the test is 90 minutes. To each question a score of 3 points is assigned. The overall score is normalized to 30. To proceed with the oral test students must reach at least 18 points out of 30.
THE FINAL GRADE IS A WEIGHTED AVERAGE OF THE MARKS OBTAINED IN EACH TESTS.

Reference texts

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Modulo: 015421/1 - GENETICA MEDICA (mutua dall'attività formativa GENETICA MEDICA - 015421/1 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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MEDICAL GENETICS
Clementi, Elementi di genetica medica, EdiSES ed.
Novelli Giardina, Genetica medica pratica, Aracne Ed.
Neri Genuardi, Genetica umana e medica, Masson – Elsevier ed.

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Modulo: 52681 - CHIMICA E BIOCHIMICA (mutua dall'attività formativa CHIMICA E BIOCHIMICA - 52681 del CdS DIETISTICA (abilitante alla professione sanitaria di Dietista) - 1050)
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CHEMISTRY AND BIOCHEMISTRY
Teacher’s handouts.
For the first part of the course anyone text of Chemistry, even high school.
For the second part:
Catani, Gasperi, Di Venere, Savini , Guerrieri, Avigliano. , Appunti di biochimica per le Lauree Triennali, Piccin, Padova
Or:
Samaja M. & Paroni R., Chimica e Biochimica per le Lauree Triennali dell’area biomedica, Piccin, Padova
or:
Stefani M. & Taddei N. (2017), Chimica e biochimica Zanichelli, Bologna
Bertoldi M., Colombo D., Magni F., Marin O., Palestini P. (2015), Chimica e biochimica, EdiSES, Napoli
For more information:
Arienti G. (2016), Le basi molecolari della nutrizione, Piccin, Padova
Ferrier D.R. , Le basi della biochimica, Zanichelli, Bologna
Or: Arienti G. (2016), Le basi molecolari della nutrizione, Piccin, Padova

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Modulo: 53064 - BIOLOGIA APPLICATA AGLI STUDI BIOMEDICI
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BIOMEDICAL BIOLOGY
-De Leo, Fasano, Ginelli, Biologia e Genetica, Edizione EdiSES
-Solomom, Berg, Martin, Elementi di Biologia, Edizione EdiSES
-Stefani e Taddei, Chimica Biochimica e Biologia Applicata, Ed. Zanichelli