PHISICAL CHEMISTRY
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- LUISA PASTI
- Credits
- 6
- Didactic period
- Primo Semestre
- SSD
- CHIM/02
Training objectives
- The course intends to provide a fundamental understanding of the theoretical principles of physical chemistry. The principal objective of the course is to provide the necessary tools to understand and apply the principles of chemical reaction kinetics and equilibrium to describe pharmaceutical and pharmacological systems.
Prerequisites
- general chemistry, mathematics and physics
Course programme
- THERMODYNAMICS
Thermodynamic systems.
Heat, work and internal energy. Entropy. Absolute temperature.
Thermodynamic equilibrium. Auxilary state functions: enthalpy, Helholtz and Gibbs free energies.
Fundamental equations. Thermal capacities. Thermochemistry. Chemical potential.
Phase transitions and equilibria (one component systems). Phase rule. Partial molar quantities, ideal and real solutions, activity.
Phase transitions and equilibria (two component systems). Phase diagrams. Reactive mixtures: chemical equilibria and equilibria constants.
CHEMICAL KINETICS
Reaction order, elementary processes, relationship between elementary processes and stechiometry.
First-order kinetic equations: integration, derivation of the kinetic constant, life time.
Second-order and nth-order kinetic equations: integration, derivation of the kinetic constant, life time.
Complex reaction schemes. Steady-state approximation, pre-equilibrium approximation, numerical examples (determination of the products concentration).
Dependence of kinetic constant on temperature.
Reaction mechanisms.
Enzimatic reactions. Didactic methods
- lessons, exercises.
Learning assessment procedures
- Written test.
The written exams, 3 numerical exercises (1 numerical exercises in thermodynamics and 1 on kinetics). and 3 questions about the whole program. Reference texts
- P. Atkins e J. De Paula, Chimica Fisica, Zanichelli
