<br />PHYSICS APPLIED TO BIOTECHNOLOGY
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- Versione italiana
- Academic year
- 2021/2022
- Teacher
- FEDERICO SPIZZO
- Credits
- 6
- Didactic period
- Secondo Semestre
- SSD
- FIS/07
Training objectives
- The aim of the lessons is to introduce some of the physical methods that can be applied to biotechnology. The knowledge acquired by the students will be: interaction between radiation and matter, notions of radioactivity and its applications in nuclear medicine, some properties of the electromagnetic waves, X-ray fluorescence and absorption spectroscopy, mass spectrometry, notions of the semiconductors physics, of chemioresistive sensors and of their applications. The main acquired abilities will concern knowing how to identify the potential of some methods of analysis and what types of information can be obtained with them.
Prerequisites
- Basic knowledge of physics and mathematics.
Course programme
- The course is divided into the following sections:
Nuclear Medicine
• Outline of the atomic structure and of the atomic nucleus. Atomic nucleus: binding energy and stability. Radioactive decays: alfa, beta and gamma [3 hours]
• Dosimetry and radioprotection. Outline of the radiation- matter interaction. Instruments for Nuclear Medicine [5 hours]
• Scintigraphy and gamma-camera. PET tomography [2 hours]
• General features of the radiopharmaceuticals. Conventional radiopharmaceuticals. Radiopharmaceuticals adopted for PET tomography [4 hours]
• Outline of radiotherapy and hadron-therapy [2 hours]
Spectroscopy and spectrometry
• Review of some topics regarding electromagnetism and the structure of matter, the electron levels in atoms, molecules and solids, and on radiation-matter interaction in the following bands: X, UV-visible e IR (5 hours)
• X Fluorescence: introduction, electronic levels involved, experimental setup, information that can be obtained with this characterization method, applications (2 hours)
• UV-Visible absorption spectroscopy: introduction, electronic levels involved, experimental setup, information that can be obtained with this characterization method, applications (3 hours)
• IR absorption spectroscopy: introduction, electronic levels involved, experimental setup, information that can be obtained with this characterization method, applications (3 hours)
• Mass spectrometry: introduction, possible analyzers: magnetic, electrostatic, quadrupole and time of flight. Applications. (3 hours)
Sensors
• Physical quantities, introduction on materials and sensors used for environmental and medical biotechnologies. (2 hours)
• Sensors classification. (4 hours)
• Introduction to the physics of semiconductors. (2 hours)
• Review of some topics regarding conductivity and detailed presentation of the chemoresistive sensors. (2 hours)
• Introduction on operando IR spectroscopy for gas sensing. (2 hours)
• Applications of chemoresistive sensors in different fields: environmental monitoring, precision agriculture, medical diagnostics. (4 hours) Didactic methods
- The course will be organized as a cycle of on-line lessons.
Learning assessment procedures
- There will be an oral examination with the aim of verifying if the student has well understood the different topics presented during the lessons and has acquired the expected abilities. The oral examination starts with the presentation of a topic chosen by the student; after that, the student will be asked some questions about the different topics presented during the lessons.
Reference texts
- • Mencuccini, Silvestrini. Fisica II. Elettromagnetismo-Ottica. Liguori editore.
• P. W. Atkins. Physical chemistry- Oxford University Press.
• D. Volterrani, P.A. Erba, G. Mariani. Fondamenti di medicina nucleare. Springer
• Documents provided by the lecturers
