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BASIC SCIENCES

Academic year and teacher
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Versione italiana
Academic year
2021/2022
Teacher
ANGELO TAIBI
Credits
8
Didactic period
Primo Semestre

Training objectives

APPLIED PHYSICS
Understanding of basic scientific knowledge useful in physiopathology of living systems
BIOCHEMISTRY
To give information in basic chemistry, useful in understanding contents of following courses. To give the basis of biochemistry such as energy metabolism and the main classes of macromolecules regulating biochemical processes of living organisms.
MEDICAL STATISTICS
Provide the skills necessary for the basic analysis of biological, clinical and organizational parameters. In particular, at the end of the course the student will learn the main methods to understand correctly scientific results, to interpret statistical inference, and to perform basic analyses on non-complex databases.
APPLIED BIOLOGY
Know the main functions of the cell and the mechanisms related to the preservation, expression and transmission of genetic information.
MICROBIOLOGY
The objective of the Microbiology module (1 CFU, 8 hours) is to provide the student with theoretical information on the main microorganisms (bacteria, viruses, fungi, parasites), their interaction with the environment and with humans and the transmission methods and prevention of infections. It will also present some pathogenic microorganisms whose transmission, through contact or air, can be prevented through the implementation of appropriate strategies.

Prerequisites

Elements of algebra and trigonometry. Basic knowledge in mathematics. Basic biology knowledge. Knowledge of human anatomy and inorganic, organic and biological chemistry. Basics of cell biology and molecular biology, with reference to synthesis and function of nucleic acids and proteins.
MICROBIOLOGY AND CLINCAL MICROBIOLOGY
no prerequisites, but basic knowledge of cell biology





Course programme

PHYSICS
The International System; scalars and vectors. Motion of a point; laws of motion; work of a force; work and kinetic energy; power; forces and potential energy; systems of mass points; centre of mass; rigid body; effects of forces on a rigid body; centre of gravity; rigid body equilibrium; work of non-conservative forces; energy conservation; fluid dynamics and statics, introduction to wave phenomena.
BIOCHEMISTRY
Length and volume measurement units, multiples and submultiples, mass and weight, density. Physical properties and states of matter, gas and vapour, equation of state, gas pressure, breathing
Basic General Chemistry. Organic chemistry in short: structural formula, isomers, asymmetric carbon atom. Hydrocarbon concept, saturated and unsaturated compounds, aliphatic and aromatic compounds, functional group and radical. Combustion, addition, substitution, polymerization reactions. The different classes of organic compounds. Hemiacetal, acetal, ester, amide. Polyfunctional compounds: hydroxyacids, ketoacids, carbohydrates, aminoacids. Soaps, chelating agents. Nucleophile and electrophile. Basic and acid organic compounds. BIOCHEMISTRY: Sugar and fat properties. Amino acid structure and isoelectric point. Protein folding and denaturation. Collagen structure. Iron metabolism and hemoglobin function. Bohr effect. ATP and Glycolysis.
MEDICAL STATISTICS
Statistical approach, design of a survey or a trial, measures of central tendency and dispersion, descriptive statistics, interpretation of the results, inferential statistics, difference between relative and absolute risk, indicators of the strength of an association, confidence intervals, hypothesis testing, concept of probability, basic principles of statistical tests and the meaning of multivariate analyses.
APPLIED BIOLOGY
Biological molecules: carbohydrates, lipids, proteins, nucleic acids. Prokaryotic cells, Eukaryotic cells: cell organelles. Biological membranes. Cell cycle, mitosis and meiosis. Structure and DNA replication. Transcription and translation.
MICROBIOLOGY AND CLINCAL MICROBIOLOGY
Prokaryotic microorganisms: Bacteria. The bacterial cell. The spore. Elements of bacterial physiology, gene exchange modalities and pathogenic action modalities. Eukaryotic microorganisms: mycetes, classification, general characteristics of mycetes; Virus: classification, viral structure, and notes on viral replication cycles and pathogenesis. Microbial growth control: notes on physical and chemical methods, sterilization, antimicrobial agents and development of drug resistance. Routes of transmission of infectious diseases and control measures. Examples of microbial pathologies transmitted from person to person by air and by direct contact. Microbiome and viroma and the concept of opportunism.



Didactic methods

BIOCHEMISTRY
Lectures, including slide shows and some exercise on the board relating to topics a) concentration of the solutions and b) pH. Involvement of students on the practical significance of the biochemical knowledge gained with questions regarding the topics.
For other modules: Lectures.
MICROBIOLOGY AND CLINCAL MICROBIOLOGY
The teaching will take place through lectures conducted by the teacher with the use of support materials (slides) that will be made available on the course minisite. Lessons will be carried out online or in presence on the basis of the indications and guidelines of the University.

Learning assessment procedures

PHYSICS
Written exam: 10 multiple choice questions (each with 5 responses). Rating: 3 for points correct answer, 0 points for wrong answer or question not answered. The correct answer is validated only if the student submits the proof. Time allotted 45 min. To pass this test it is required to get at least 18 points out of 30.
MEDICAL STATISTICS
Written test: 15 multiple choice questions, each with 4 answers. More than a correct answer is possible, from one to four for each question. Every question is worth 2 points; every wrong answer or a correct answer that has not been indicated, minus 1 point. Duration: 30 minutes. To pass the exam, the score has to be 18 or higher.
BIOCHEMISTRY
Written exam lasting 1 hour and half.
Chemistry part: 20 questions with 3 answers for each question, right question 1 point, wrong or not answered 0 point. Minimal rank to overcome this part is 7, maximal 16 if all is right. Biochemistry part: 10 multiple choice questions and 5 with open answer.
Final mark will be the sum of the chemistry and biochemistry rank. Laude which consists of one more point will be gained if all done is right.
APPLIED BIOLOGY
The test includes a written test consisting of 31 questions, some of which provide a closed answer and some questions are open-ended. For each correct answer 1 point and no points for answers not given or incorrect. Verification with 31 positive responses on / 31 total, provides a score of 30/30 and laud. The written test lasts 45 minutes.
MICROBIOLOGY AND CLINCAL MICROBIOLOGY
The exam will be oral or written in the form of multiple choice questions (31 multiple choice questions with 5 answers each of which one correct; time available 15-20 minutes). Evaluation: 1 point for correct answer, 0 points for wrong answer or not given. To pass the test it is necessary to acquire at least 18 points out of 30. The test with 31 positive answers out of 31 total requires a score of 30/30 and honors. The oral or written exams will be conducted online or in presence according to the University's indications and guidelines.

THE FINAL GRADE IS A WEIGHTED AVERAGE OF THE MARKS OBTAINED IN EACH TEST.


Reference texts

APPLIED PHYSICS
A. Lascialfari, F. Borsa, A. M. Gueli. Principi di Fisica. EdiSES (III ed.)
Materials provided by the teacher.
MEDICAL STATISTICS
Manzoli L, Villari P, Boccia A. Epidemiologia e Management in Sanità. Elementi di Metodologia (2° Ed.). Edi-Ermes, 2015. Material provided by the teacher.
Teacher’s handouts.
BIOCHEMISTRY
For the first part of the course is simply any text of Chemistry, even high school.
For the second part: Catani, Savini, Guerrieri, Avigliano, Appunti di biochimica per le Lauree Triennali, Piccin Ed. or: Samaja, Corso di biochimica per le Lauree Sanitarie, Piccin Ed.
Or a text that contains both sides of Chemistry to Biochemistry: Stefani, Taddei, Chimica, biochimica e biologiaapplicata, Zanichelli Ed.
BIOLOGY
Solomom, Berg, Martin, Elementi di Biologia, Edizione EdiSES
Stefani e Taddei, Chimica Biochimica e Biologia Applicata, Ed. Zanichelli
De Leo, Fasano, Ginelli, Biologia e Genetica, Edizione EdiSES.
MICROBIOLOGY AND CLINCAL MICROBIOLOGY
Principi di Microbiologia Clinica - Eudes Lanciotti – Casa Editrice Ambrosiana- quarta edizione