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GENERAL PATHOLOGY

Academic year and teacher
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Versione italiana
Academic year
2022/2023
Teacher
PAOLO PINTON
Credits
7
Didactic period
Secondo Semestre
SSD
MED/04

Training objectives

Objective of the general pathology course is the ethiology and the pathogenesis of the diseases. In particular the course will focus on the mechanisms involved in the functional and morphological changes of the acute and chronic inflammatory response, wound healing. The course will also focus on the molecular mechanisms leading to alteration of the growth and cellular differentiation, innate and acquired immunity, immunopathological reaction.

Prerequisites

Basic knowledge of biochemistry, microbiology and physiology

Course programme

Concepts of aetiology and pathogenesis
Cellular pathology: necrosis, apoptosis and autophagy
Pathogenesis by physical agents: radiation
Mechanism of action and biotechnological use of bacterial toxins.
Inflammation: acute and chronic, inflammatory cells, endogenous and exogenous mediators of inflammation, exudate, granuloma, systemic reaction to inflammation, wound healing.
Immunology: innate and acquired immunity, lymphoid organs and cells of the immune system, co-operation among cells during the immune response, antigen presentation, T and B lymphocytes, structure and classes of immunoglobulins, hypersensitivity type 1, 2, 3 and 4.
Tumors: Alteration of cell growth and differentiation, epidemiology of tumors, histopathological features of tumor cells, tumor growth and angiogenesis, promotion and initiation, cancerogenesis by chemical, physical and biological agents, oncogenes, metastasis, immunity against tumors.

Didactic methods

Lectures

Learning assessment procedures

The aim of the examination is to test the level of achievement of learning objectives previously indicated..
A quiz (multiple choice questions) on the basic concepts of the course (Each correct answer = 1 point; each wrong answer = -0.5; no answer = 0)
The time for this test is 1 hour.
It is not allowed to consult texts or use PCs, smart phones, calculators, .... ;

Reference texts

Rubin, Patologia Generale
Robbins, Le basi molecolari delle malattie
Janewa, Immunobiologia.