MOLECULAR PATHOGENESIS OF ACUTE LYMPHATIC LEUKEMIA
Academic year and teacher
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- Versione italiana
- Academic year
- 2020/2021
- Teacher
- CAROLINA SIMIONI
- Credits
- 1
- Didactic period
- Secondo Semestre
- SSD
- MED/38
Training objectives
- The main objective of the course is to provide students with an in-depth characterization of acute lymphatic leukemia (ALL), its incidence in adult and pediatric age, the prognostic factors of the disease, the predominant molecular and cytogenetic bases, the current therapies used in the clinic and the development of possible new targeted therapies
Prerequisites
- Students must have a basic knowledge of cell biology, cellular and molecular Immunology and the main characteristics of lymphatic cells
Course programme
- Epidemiology, pathogenesis and symptomatology of ALL
Morphology, cytochemistry and classification of ALL
Molecular biology methods for the characterization of ALL with references to cytogenetic alterations
Main aberrant or mutated signal transduction pathways in ALL
ALL therapy: analysis of traditional pharmacological protocols and development of new therapeutic strategies Didactic methods
- Frontal lessons and material on Moodle platform
Learning assessment procedures
- The exam will consist of a multiple choice test of 31 questions. To pass the exam it is necessary to acquire a minimum score of 18 (corresponding to 18 correct answers out of 31). The correct answer to all the questions is the score of 30 with lode. The estimated time for the test is 1 hour.
Reference texts
- Childhood Acute Lymphoblastic Leukemia 1st ed. 2017 Edition- Editore: Ajay Vora
