Salta ai contenuti. | Salta alla navigazione

Strumenti personali

MOLECULAR AND FUNCTIONAL BASES OF LIFE

Academic year and teacher
If you can't find the course description that you're looking for in the above list, please see the following instructions >>
Versione italiana
Academic year
2022/2023
Teacher
TIZIANA BELLINI
Credits
8
Didactic period
Primo Semestre

Training objectives

------------------------------------------------------------
Modulo: 000061/1 - BIOCHIMICA
------------------------------------------------------------
BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines.

------------------------------------------------------------
Modulo: 009824/2 - CHIMICA MEDICA
------------------------------------------------------------
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.

------------------------------------------------------------
Modulo: 010216/1 - STATISTICA MEDICA
------------------------------------------------------------
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.

------------------------------------------------------------
Modulo: 015421/1 - GENETICA MEDICA
------------------------------------------------------------
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic knowledge of physics able to solve primary physics problem included in the whole curriculum study.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.


------------------------------------------------------------
Modulo: 015440/3 - BIOLOGIA APPLICATA
------------------------------------------------------------
APPLIED BIOLOGY
To provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.

------------------------------------------------------------
Modulo: 26804 - FISICA APPLICATA
------------------------------------------------------------
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic knowledge of physics able to solve primary physics problem included in the whole curriculum study.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.


------------------------------------------------------------
Modulo: 26805 - INFORMATICA
------------------------------------------------------------
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic knowledge of physics able to solve primary physics problem included in the whole curriculum study.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.


------------------------------------------------------------
Modulo: 53261 - SEMINARIO DI INFORMATICA
------------------------------------------------------------
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic knowledge of physics able to solve primary physics problem included in the whole curriculum study.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.

Prerequisites

------------------------------------------------------------
Modulo: 000061/1 - BIOCHIMICA
------------------------------------------------------------
Basic concepts of chemistry. Very basic knowledge of the structure of atoms, nature of chemical bonds and aggregation states of the matter.

------------------------------------------------------------
Modulo: 009824/2 - CHIMICA MEDICA
------------------------------------------------------------
Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.

------------------------------------------------------------
Modulo: 010216/1 - STATISTICA MEDICA
------------------------------------------------------------
Conoscenza di base della epidemiologia e della biostatistica.


------------------------------------------------------------
Modulo: 015421/1 - GENETICA MEDICA
------------------------------------------------------------
Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.

------------------------------------------------------------
Modulo: 015440/3 - BIOLOGIA APPLICATA
------------------------------------------------------------
APPLIED BIOLOGY
Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.
MEDICAL STATISTICS: Basic knowledge of epidemiology and biostatistics.

------------------------------------------------------------
Modulo: 26804 - FISICA APPLICATA
------------------------------------------------------------
Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.

------------------------------------------------------------
Modulo: 26805 - INFORMATICA
------------------------------------------------------------
None.

------------------------------------------------------------
Modulo: 53261 - SEMINARIO DI INFORMATICA
------------------------------------------------------------
None.

Course programme

------------------------------------------------------------
Modulo: 000061/1 - BIOCHIMICA
------------------------------------------------------------
BIOCHEMISTRY
Structure and function of carbohydrates, lipids, amino acids and proteins. Hemoglobin and myoglobin. Enzymes. ATP and Metabolism with the different steps in energy extraction from nutrients. Localization of metabolic pathways in the cell. Coenzymes and main metabolic pathways.

------------------------------------------------------------
Modulo: 009824/2 - CHIMICA MEDICA
------------------------------------------------------------
MEDICAL CHEMISTRY
Atom and radioactivity. Chemical bonds. Gas Law. Solutions and determination of their concentration. Chemical equilibrium: principle of mobile equilibrium and law of action of the masses. Acids, Bases and Salts. Buffer solutions, buffers of the blood pH and its measurement. Osmotic pressure and osmolarity: hypo-hyper and isotonic solutions, physiological solutions. Elements of organic chemistry (recognition of functional groups only).

------------------------------------------------------------
Modulo: 010216/1 - STATISTICA MEDICA
------------------------------------------------------------
The course will be structured around the following topics:
1) Descriptive Statistics: central tendency and variability indexes.
2) The fundamentals of probability as applied to diagnostic tests and biomedical research.
4) Statistical inference: Interval estimates (confidence intervals) and hypothesis testing with applications and examples in clinical research.
6) Inference on categorical data: the main measures of association such as Odds Ratio (OR) and Relative Risk (RR).



------------------------------------------------------------
Modulo: 015421/1 - GENETICA MEDICA
------------------------------------------------------------
MEDICAL GENETICS
General concepts of genetics: genes, alleles, genotype, phenotype. Mendel's laws. Independent genes and associated genes. Codominance and multiple allelia (examples: System AB0 and HLA). Genomic,
chromosomal and gene mutations with examples of associated pathologies. Mendelian transmission of autosomal dominant, autosomal recessive and X-associated genetic diseases and transmission of
mitochondrial diseases. Analysis of family trees.

------------------------------------------------------------
Modulo: 015440/3 - BIOLOGIA APPLICATA
------------------------------------------------------------
APPLIED BIOLOGY
Biological macromolecules: carbohydrates, proteins, nucleic acids. Lipids and cell membranes. Replication and transcription of DNA; translation of RNA. Genetic code. Organization of the cell. Major differences between cells of prokaryotes and eukaryotes. Eukaryotic cell components: nucleus, nucleolus, rough and smooth endoplasmic reticulum, ribosomes, Golgi apparatus, lysosomes, mitochondria, centrioles, cytoskeleton. Chromatin structure. Euchromatin and heterochromatin. From DNA to chromosomes. Protein sorting and endocytosis in cellular compartments. Membranes and transport mechanisms. Mechanisms of cell signaling. Cell cycle. Mitosis. Meiosis.

------------------------------------------------------------
Modulo: 26804 - FISICA APPLICATA
------------------------------------------------------------
APPLIED PHYSICS
Introductory topics in the course: definition of the percentage difference, elements of trigonometry, right triangle theorem. Logarithm and exponential function. Scientific notation, physical, vectors, Cartesian vectors, vector calculus.
- Point motions: rectilinear motion uniform and uniformly accelerated.
- Dynamic: three principles of dynamics, definition of work, work and kinetic energy, work and potential energy, conservation of energy
- Moment of a force and rotation of a body. Levers and their application in the human body.
- Fluid: pressure definition, Pascal's principle, Stevino, continuity equation, Archimedes' law, Bernoulli equation, fluid viscosity and resistance to movement, practical applications of the fluid dynamics in the human body.

------------------------------------------------------------
Modulo: 26805 - INFORMATICA
------------------------------------------------------------
Data and information. Basic components and functions of a computer system. Data processing: algorithm. Binary encoding. Hardware components. Software components. Function, structure and types of an operating system. Application software. File. Data storage and mass storage. File System. Data protection. Computer security and web navigation.
Basic elements of the spreadsheet. Editing commands. Graphical, numerical and conditional formatting of cells. Formulas and main logical, statistical, mathematical functions. Charts.

------------------------------------------------------------
Modulo: 53261 - SEMINARIO DI INFORMATICA
------------------------------------------------------------
Exercises on the use of the spreadsheet.
Analysis of experimental data through the most common descriptive statistics functions. Sorting and filtering data. Pivot tables.

Didactic methods

------------------------------------------------------------
Modulo: 000061/1 - BIOCHIMICA
------------------------------------------------------------
Lectures + Google Classroom use for communications, exercises and store of useful material.

------------------------------------------------------------
Modulo: 009824/2 - CHIMICA MEDICA
------------------------------------------------------------
lectures and self-assessment focus

------------------------------------------------------------
Modulo: 010216/1 - STATISTICA MEDICA
------------------------------------------------------------
The teaching activity of the course is organized in classroom lessons.


------------------------------------------------------------
Modulo: 015421/1 - GENETICA MEDICA
------------------------------------------------------------
Lectures

------------------------------------------------------------
Modulo: 015440/3 - BIOLOGIA APPLICATA
------------------------------------------------------------
Lectures + hands-on computer lab

------------------------------------------------------------
Modulo: 26804 - FISICA APPLICATA
------------------------------------------------------------
Lectures

------------------------------------------------------------
Modulo: 26805 - INFORMATICA
------------------------------------------------------------
Lectures.
NB: if you have it, is suggested to bring a laptop to the lectures.

------------------------------------------------------------
Modulo: 53261 - SEMINARIO DI INFORMATICA
------------------------------------------------------------
Lectures (no computer lab).
NB: if you have it, is suggested to bring your own personal PC.

Learning assessment procedures

MEDICAL CHEMISTRY
Multiple-choice written test (4 possible answers) composed by 11 questions about the subjects of the course. Starting points: 10. Each correct answer scores 2 points; no penalties for wrong or not answered question. To pass the exam, it is necessary to score at least 8 points (4 questions), corresponding to 18/30. The final score corresponds to the final grade of the exam. The time allowed is 15 minutes.
BIOCHEMISTRY
Multiple-choice written test (3-4 possible answers with only one correct) composed by 18 questions about the subjects of the course. Each correct answer scores 2 points; no penalties for wrong or not answered question. To pass the exam, it is necessary to score at least 18 points (9 correct answers), corresponding to 18/30 as final grade of the exam. Maximal grade 31 with all correct answers. The time allowed is 30 minutes.
BIOLOGY
Written exam: 20 multiple choice (5 options) questions. The score for each correct answer is 1.55 points. Wrong or not given answers have a score of 0 points. Time available: 30 minutes.
GENETICS
Written test, with the administration of 10 multiple choice questions (3-4 options). Each correct answer corresponds to 3 points, wrong answers are worth 0 points. Total time available: 30 minutes.
APPLIED PHYSICS
A written examination with 18 multiple choice quizzes, each with four possible answers. Valuation: each correct answer two points; answer not given or wrong zero points. The vote obtained will be converted into thirtieths. Duration: 30 minutes.
MEDICAL STATISTICS
A written examination with closed-ended questions.
COMPUTER SCIENCE AND COMPUTER SEMINAR
Written exam consisting of 30 multiple choice questions (with 1 correct answer) divided into 2 macro-topics: Basic computer science 15 questions; Spreadsheet 15 questions.
Rating:
1 point for correct answer
0 points for wrong or undated answer.
Duration: 30 minutes.
The exam is considered passed only if, regardless of the overall score achieved, at least 9 answers are correct for each macro-topic

THE FINAL GRADE IS A ARITHMETIC AVERAGE OF THE MARKS OBTAINED IN EACH TESTS.

Reference texts

------------------------------------------------------------
Modulo: 000061/1 - BIOCHIMICA
------------------------------------------------------------
-Every Biochemistry text can go however synthetic texts are suggested, such as
M. Stefani, N. Taddei, Chemistry, Biochemistry and Applied Biology, Ed Zanichelli or Stefani e Taddei, Chemistry and Biochemistry, Ed Zanichelli.
Otherwise Catani ecc. Appunti di Biochimica, Piccin ed. or Samaja e Paroni, Chimica e Biochimica, Piccin Ed or Bertoldi ecc., Chimica e Biochimica, EdiSES.

+teaching materials provided by teachers.

------------------------------------------------------------
Modulo: 009824/2 - CHIMICA MEDICA
------------------------------------------------------------
MEDICAL CHEMISTRY
M. Stefani, N. Taddei, Chemistry, Biochemistry and Applied Biology, Ed Zanichelli and teaching materials provided by teachers.

------------------------------------------------------------
Modulo: 010216/1 - STATISTICA MEDICA
------------------------------------------------------------
• Martin Bland, Statistica Medica, Apogeo Ed. 2009.
• Marcello Pagano, Kimberlee Gauvreau, Fondamenti di Biostatistica, Idelson Gnocchi 2003.
• Bernard Rosner, Fundamentals of Biostatistics, Cengage Learning 2011.


------------------------------------------------------------
Modulo: 015421/1 - GENETICA MEDICA
------------------------------------------------------------
GENETICS
Neil A., Campbell, Jane B. Reece, Biologia- La genetica, Zanichelli Ed.
M.R. Cummings,Eredità, EdiSES
B. A. Pearce, Genetica, Zanichelli Ed.
Alternatively, after consultation with the teacher, any updated text of Genetics

------------------------------------------------------------
Modulo: 015440/3 - BIOLOGIA APPLICATA
------------------------------------------------------------
MEDICAL CHEMISTRY, BIOCHEMISTRY AND APPLIED BIOLOGY
M. Stefani, N. Taddei, Chemistry, Biochemistry and Applied Biology, Ed Zanichelli and teaching materials provided by teachers.

------------------------------------------------------------
Modulo: 26804 - FISICA APPLICATA
------------------------------------------------------------
APPLIED PHYSICS
Monaco, R. Sacchi, A. Solano, Elementi di Fisica, McGraw Hill and handouts by the teacher.

------------------------------------------------------------
Modulo: 26805 - INFORMATICA
------------------------------------------------------------
None, not needd. The slides cover all the arguments.

------------------------------------------------------------
Modulo: 53261 - SEMINARIO DI INFORMATICA
------------------------------------------------------------
None.