BIOTECHNOLOGICAL PRODUCTS FOR HEALTH
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- STEFANO MANFREDINI
- Credits
- 6
- Didactic period
- Secondo Semestre
- SSD
- CHIM/08
Training objectives
- Cognitive: knowledge of the main pharmaceutical categories, raw materials and production aspects. theory and methods for studying structure-activity relationships of drugs and bioactive molecules; interactions between ligands and macromolecules; structure, shape and conformation; methods applied to the study of structure-activity relationships; drug design at companies and public research centers. - Operational: knowledge of problems related to the preparation of biotechnology products; ability to see and try some preparation techniques or protocols. ability to analyze the behavior of bioactives in relation to their structure. -Behavioral: The goal of this discipline is to prepare the student for professional life either in industry or academia. ability to process knowledge in a Team environment. In particular, the pharmacy student has to compendize also through project works the knowledge acquired in the Pharmaceutical, Pharmacological, Pharmacognostic and Dietary fields by understanding that the mechanisms of preparation and structure-function relationships are transversal to the pharmaceutical, cosmetic, herbal and food fields.
Prerequisites
- knowledge of Pharmaceutical Chemistry, Cosmetic Chemistry, Dietetics, Pharmacology, Pharmaceutical Technology, Herbal Products
Course programme
- Innovation and invention: the discovery and development of bioactive molecules in a changing world definitions. Relationships structure and function of molecules The drug and health product industry the forces of change, from design to production of bioactive molecules, reasons for success. Sustainability in pharmaceuticals: environmental, social and economic. Elements of translational medicine. Biotechnology: products and processes. Preparation by fermentation, recombinant DNA and zootechnics, of biologically active molecules and drugs. Production techniques in the laboratory: heating, cooling, precipitation, filtration, crystallisation, concentration, distillation and chromatography. biological and biotechnological drugs, gene therapy vectors, molecular and cellular therapies. Optimisation of production processes: process validation, recovery rate and yield, purity yield. Preparation of therapeutic proteins: transgenic animals, plants and bioreactors: pros and cons. Contaminants. The purification process. Monoclonal antibodies: synthesis of antibodies and their conjugates (ADC) (20 hours). Biotechnological ingredients for cosmetic use: design, preparation, production, structure-action relationships. Biotechnological ingredients for nutritional use: design, preparation, production, structure-action relationships. Examples of biotechnological drugs, cosmetics and supplements.
Didactic methods
- Theoretical/practical lessons. Individual Project work on selected biotech drugs, cosmetics and food supplements.
Learning assessment procedures
- La verifica di apprendimento può essere condotta con prove scritte e/o orali. La modalità mista consiste nella discussione di un project work (che rappresenta la prova scritta) e riguarda la produzione di un progetto di lavoro individuale in presentazione tipo ppt su un ingrediente biotecnologico per ogni categoria presentata a lezione (Farmaco, Cosmetico, Integratore) a scelta dello studente e redatto secondo le istruzioni fornite in classe e presenti sulla Classroom del corso. La verifica orale prevede anche domande su argomenti trattati in classe e non nel project work.
Reference texts
Materials provided by lecturer
Foye's Principles of Pharmaceutical Chemistry
Revised and corrected reprint
THOMAS L. LEMKE - DAVID A. WILLIAMS - FOYE 2021
Chimica farmaceutica. Alberto Gasco (Autore), Fulvio Gualtieri (Autore), Carlo Melchiorre (Autore) Casa Editrice Ambrosiana Ed. 2020
