BIOCHEMISTRY AND MOLECULAR BIOLOGY
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- RICCARDO GAVIOLI
- Credits
- 12
- Didactic period
- Primo Semestre
Training objectives
- The main objective of this integrated course is to provide students with the basics to face the study and understanding of the chemical nature and structure of the constituents of living matter, of biomolecule transformations, of energy changes associated with them and of metabolism of nucleic acids, and to apply this knowledge for the evaluation of the impact of structural variations of biomolecules on their function, of the effect of modulators of biomolecules in the pharmaceutical / therapeutic field and to understand how physiological changes impact on the metabolism and on the life of cells.
Prerequisites
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Modulo: 002617/1 - BIOLOGIA MOLECOLARE
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General concept of cellular biology. To take the final examination (learning assessment procedures), students must have passed the exam of organic chemistry.
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Modulo: 28121 - BIOCHIMICA
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General concept of cellular biology and chemistry. To take the final examination (learning assessment procedures), students must have passed the exam of organic chemistry. Course programme
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Modulo: 002617/1 - BIOLOGIA MOLECOLARE
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Molecular Biology:
STRUCTURE OF NUCLEIC ACIDS
Chemical structure of nucleic acids
Physical structure of DNA
DNA topology and DNA topoisomerase
Structure of RNA
The genome structure, chromatin, and nucleosomes
GENE EXPRESSION and REGULATION
RNA transcription
RNA processing
Transcription regulation in prokaryotes and eukaryotes
REPLICATION and MAINTENANCE OF GENOME
Translation
Translation regulation
REGULATION OF GENETIC INFORMATION
DNA replication
DNA mutation and repair
Homologous recombination
Site-specific recombination and transposons
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Modulo: 28121 - BIOCHIMICA
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Molecular Biology:
STRUCTURE OF NUCLEIC ACIDS
Chemical structure of nucleic acids
Physical structure of DNA
DNA topology and DNA topoisomerase
Structure of RNA
The genome structure, chromatin, and nucleosomes
GENE EXPRESSION and REGULATION
RNA transcription
RNA processing
Transcription regulation in prokaryotes and eukaryotes
REPLICATION and MAINTENANCE OF GENOME
Translation
Translation regulation
REGULATION OF GENETIC INFORMATION
DNA replication
DNA mutation and repair
Homologous recombination
Site-specific recombination and transposons
Biochemistry:
STRUCTURES, PROTEIN FUNCTIONS AND CATALYSIS
Biomolecules. Amino acids, peptides and proteins. Three-dimensional structure of proteins. Hemoglobin and myoglobin. Enzymes. Lipids. Biological membranes and transport. Signal transduction cascades.
BIOENERGETICS AND METABOLISM
Principle of bioenergetics. Glycolysis and catabolism of hexoses. Glycogenolysis and glycogen synthesis. The pentose phosfate patway. The citric acid cycle. Oxidation of fatty acids. Amino acid oxidation. Oxidative phosphorylation. Carbohydrate biosynthesis. Lipid biosynthesis. Integration of hormonal regulation of mammalian metabolism. Didactic methods
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Modulo: 002617/1 - BIOLOGIA MOLECOLARE
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Theoretical lessons. The student is guided along the path, to arrive at an understanding of the relationship between the structure and function of macromolecules, and the strategies for regulating their functions in the context of metabolic reactions. The students will be actively involved in the discussion of the themes of the course.
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Modulo: 28121 - BIOCHIMICA
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Theoretical lessons. The student is guided along the path, to arrive at an understanding of the relationship between the structure and function of macromolecules, and the strategies for regulating their functions in the context of metabolic reactions. The students will be actively involved in the discussion of the themes of the course. Learning assessment procedures
- The aim of the evaluation is to test the level of knowledge and deepening of the topics of the course program and the reasoning skills developed by the student on issues related to biochemistry and molecular biology by two written tests constituted by multiple choice questions and open questions.
Reference texts
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Modulo: 002617/1 - BIOLOGIA MOLECOLARE
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Schemes and figures showed by the professors during the lessons.
Watson JD et al, Biologia molecolare del gene, Zanichelli, 2022
I Principi di Biochimica di Lehninger di DL. Nelson e MM. Cox
Zanichelli Editore
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Modulo: 28121 - BIOCHIMICA
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Schemes and figures showed by the professors during the lessons.
Watson JD et al, Biologia molecolare del gene, Zanichelli
I Principi di Biochimica di Lehninger di DL. Nelson e MM. Cox
Zanichelli Editore
